Trimethylsilylacetylene → 2,2,2-Trifluoro-N-{2-(methyloxy)-5[(trimethylsilyl)ethynyl]phenyl}-acetamide

Participants

Reaction Steps

N-[5-Bromo-2-(methyloxy)phenyl]-2,2,2-trifluoroacetamide (5.79 g, 19.4 mmol) and (trimethylsilyl)acetylene (4.1 mL, 29.1 mmol) were coupled according to the procedure of Example 56, Step B to give the desired product (2.32 g, 38%). ES-LC/MS m/z=314 [M−H]−.

Provenance & Evidence