4-Amino-2-chlorobenzonitrile → HCID 11988440, compound

Participants

Reaction Steps

Dissolve methanesulfonic acid 4-methanesulfonyloxy-1-phenyl-hexyl ester (1.01 g, 2.88 mmol) in toluene (20 mL) in a reaction tube. Add 4-amino-2-chlorobenzonitrile (1.10 g, 7.2 mmol), purge with nitrogen and cap. Heat the reaction in a 120° C. oil bath for 17 h. Cool, concentrate, and purify by silica gel chromatography using 5-30% EtOAc/hexanes to obtain 0.22 g (25%0 of the title compound as a clear oil. MS (ESI+): 311 (M+1)+, 309 (M−1)−.

Provenance & Evidence