4-Amino-2-chloro-3-methylbenzonitrile → HCID 11988441, compound

Participants

Reaction Steps

Dissolve methanesulfonic acid 4-methanesulfonyloxy-1-phenyl-hexyl ester (381 mg, 1.09 mmol) in toluene (10 mL) in a reaction tube. Add 4-amino-2-chloro-3-methylbenzonitrile (363 mg, 2.18 mmol), purge with nitrogen and cap. Heat the reaction in a 120° C. oil bath for 17 h. Cool, concentrate, and purify by silica gel chromatography using 5-30% EtOAc/hexanes to obtain 7 mg (1%) of the title compound (a mixture of 4 isomers) as a clear oil. MS (ESI+): 325 (M+1)+.

Provenance & Evidence