Hydrochloric Acid → HCID 59511511, compound

Participants

Reaction Steps

To a flask containing methyl 2-(7-(5-(3-hydroxypentan-3-yl)-1H-pyrazol-3-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetate (0.066 g, 0.171 mmol) was added MeOH (1 mL) and Water (1 mL). To the mixture was added potassium carbonate (0.118 g, 0.854 mmol). After 1 h, the mixture was made acidic (pH=1) by adding 1N HCl. No precipitate formed, so the solvent was removed under reduced pressure. The crude mixture containing 2-(7-(5-(3-hydroxypentan-3-yl)-1H-pyrazol-3-yl)-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-oxoacetic acid was carried forward to the next step with no further purification. LCMS: m/e 373.22 (M+H)+, ret time 1.723 min (method 4).

Provenance & Evidence