HCID 59511173, compound → HCID 59511163, compound

Participants

Reaction Conditions

Reaction Steps

Tert-butyl-4-(2-phenyl-4,5-dihydro-1H-imidazol-1-yl)piperidine-1-carboxylate (0.1 g) and nickel peroxide was dissolved in dry benzene (20 ml) and refluxed at 100° C. for over-night. Reaction mixture was allowed to come to room temperature, filtered through a celite pad and washed with CHCl3 (2×20 ml). The organic solvent removed under reduced pressure gave an oil, which was purified by column chromatography using ethyl acetate. Evaporation of solvent gave pure product, tert-butyl 4-(2-phenyl-1H-imidazol-1-yl)piperidine-1-carboxylate.

Provenance & Evidence