HCID 59511172, compound → HCID 59511291, compound

HRID 1157825Notes

Reaction equation

HRID 1157825 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([N:14]2[CH2:19][CH2:18][N:17]([C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:21])[CH2:16][CH2:15]2)[CH:3]=1>CO.[C].[Pd]>[C:22]1([C:20]([N:17]2[CH2:18][CH2:19][N:14]([C:4]3[CH:3]=[CH:2][N:7]=[N:6][C:5]=3[C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH2:15][CH2:16]2)=[O:21])[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

4

Reactant 1

HCID 59511172HCID 59511172, compound

Product 1

HCID 59511291HCID 59511291, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To (4-(6-chloro-3-phenylpyridazin-4-yl)piperazin-1-yl)(phenyl)methanone (1 g) dissolved in methanol (40 ml), and palladium carbon (10 mol %) was added very slowly under nitrogen atmosphere and the reaction mixture was stirred under hydrogen atmosphere (1 kg pressure) for 3 hrs. The progress of reaction was monitored by TLC. After consumption of starting material, the reaction mixture was filtered through celite, washed with methanol and the filterate was concentrated under reduced pressure to get phenyl(4-(3-phenylpyridazin-4-yl)piperazin-1-yl)methanone as white solid.

Workup

  1. customThe progress of reaction
  2. customAfter consumption of starting material
  3. filtrationthe reaction mixture was filtered through celite
  4. washwashed with methanol
  5. concentrationthe filterate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-20df79a4795d4219b52116d8d42ac566
Source dataset
uspto-grants-2010_10
Patent number
US07807676B2

Reaction notes

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