Sodium Hydroxide → HCID 135999727, compound

HRID 1157961Notes

Reaction equation

HRID 1157961 reaction equation
C([O:3][C:4]([C:6]1[N:7]([CH2:47][CH:48]=[CH2:49])[CH:8]=[N:9][C:10]=1[N:11]1[C:15](=[O:16])[NH:14][C:13]([CH:17]([NH:29][C:30]2[CH:35]=[CH:34][C:33]([C:36]#[N:37])=[C:32]([CH2:38][NH:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH:31]=2)[C:18]2[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH3:27])=[CH:20][C:19]=2[F:28])=[N:12]1)=[O:5])C.[OH-].[Na+]>CO>[CH2:47]([N:7]1[C:6]([C:4]([OH:5])=[O:3])=[C:10]([N:11]2[C:15](=[O:16])[NH:14][C:13]([CH:17]([NH:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]#[N:37])=[C:32]([CH2:38][NH:39][C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])[CH:31]=3)[C:18]3[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH3:27])=[CH:20][C:19]=3[F:28])=[N:12]2)[N:9]=[CH:8]1)[CH:48]=[CH2:49]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 135999730HCID 135999730, compound

Product 1

HCID 135999727HCID 135999727, compoundYield 15.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a mixture of 3-allyl-5-(3-{[3-(t-butoxycarbonylaminomethyl)-4-cyanophenylamino]-(2-fluoro-4,5-dimethoxyphenyl)methyl}-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl)-3H-imidazole-4-carboxylic acid ethyl ester (17 mg) and methanol (1 mL) there was added a 5N sodium hydroxide aqueous solution (0.10 mL), and the mixture was stirred overnight at room temperature. The mixture was purified by reverse-phase high performance liquid chromatography (acetonitrile/water mixed solvent, 0.1% acetic acid) to obtain the target compound (2.5 mg).

Workup

  1. customThe mixture was purified by reverse-phase high performance liquid chromatography (acetonitrile/water mixed solvent, 0.1% acetic acid)

Sources & evidence

ORD record
ord-9c4e584c6ca44e8a83ae4042aaf03c43
Source dataset
uspto-grants-2010_10
Patent number
US07807690B2

Reaction notes

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