Toluene → HCID 178492952, compound

Participants

Reaction Steps

To a mixture of 3-allyl-5-(3-{[3-(t-butoxycarbonylaminomethyl)-4-cyanophenylamino]-(2-fluoro-4,5-dimethoxyphenyl)methyl}-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl)-3H-imidazole-4-carboxylic acid (2.5 mg) in dichloromethane (2 mL) there were added tetrakis(triphenylphosphine)palladium(0)(0.5 mg) and 1,3-dimethylbarbituric acid (1.5 mg) under a nitrogen atmosphere, and the mixture was stirred overnight at room temperature. Trifluoroacetic acid (0.4 mL) was added, the mixture was stirred at room temperature for 30 minutes, and then toluene (10 mL) was added to the mixture and the solvent in the mixture was distilled off. The residue was purified by reverse-phase high performance liquid chromatography (acetonitrile/water mixed solvent, 0.1% acetic acid) to obtain the target compound (0.25 mg).

Provenance & Evidence