Sodium Hydroxide → HCID 59014309, compound

Participants

Reaction Steps

The methyl ester (15a) obtained above (2.7 mg, 0.006 mmol) was dissolved in THF (600 μL) and to the resultant solution was added 300 μL of a 3M NaOH(aq) and the reaction solution was stirred at rt. The crude product 16a was purified by HPLC (MeCN/H2O/0.1% TFA) to give 1.5 mg (16a): LC-MS (Method B, retention time=2.172 min. MS calc'd for C27H34N3O3 (MH+): 448.3. Found 448.5.

Provenance & Evidence