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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1158082Generated: October 31, 2026

4-(2-(4-Methyl-3-nitrophenoxy)ethyl)morpholine → 2-Methyl-5-[2-(morpholin-4-yl)ethoxy]aniline

https://huagongshe.com/reaction/1158082

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(2-(4-Methyl-3-nitrophenoxy)ethyl)morpholineHCID 58929867—
CatalystPalladiumHCID 23938—
SolventMethanolHCID 887—
Product2-Methyl-5-[2-(morpholin-4-yl)ethoxy]anilineHCID 39335039—

Reaction Steps

To the mixture of 4-(2-(4-methyl-3-nitrophenoxy)ethyl)morpholine (532 mg, 2 mmol) in MeOH (50 mL) was added 10% Pd/C (250 mg). The mixture was stirred under an atmosphere of H2 (balloon) overnight. The contents of the reaction mixture were then filtered and concentrated in vacuo to give the title product, which was used without further purification.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07807700B2
Source datasetuspto-grants-2010_10
ORD IDord-808f4509d16948bc8ff9b78cf976924c
Source noteuspto-grants-2010_10