HRID1158152

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10796

Cesium carbonate

CCs2O3

HCID582370

(4-bromobutoxy)(tert-butyl)dimethylsilane

C10H23BrOSi

结构：CCOC(=O)c1ccc(-c2ccc(O)c(-c3ccc(NCCC(C)=O)c(C(C)(C)C)c3)c2)cc1

HCID86617903

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1ccc(-c2ccc(OCCCCO[Si](C)(C)C(C)(C)C)c(-c3ccc(NCCC(C)=O)c(C(C)(C)C)c3)c2)cc1

HCID131728358

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

In a manner similar to that of Example 2a, by reacting 260 mg of ethyl 4″-(acetylethylamino)-3″-tert-butyl-4′-hydroxy[1,1′;3′,1″]terphenyl-4-carboxylate (0.56 mmol) in 12 mL of dimethylformamide with 225 mg of caesium carbonate and 0.16 mL of 1-bromo-4-(tert-butyldimethylsilanyloxy)butane, 310 mg of ethyl 4″-(acetylethylamino)-3″-tert-butyl-4′-[4-(tert-butyldimethylsilanyloxy)butoxy]-[1,1′;3′,1″]terphenyl-4-carboxylate (yield=99%) are obtained in the form of an oil.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2590a40f333946a38eaa341bdf71cae5
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07807708B2
来源说明: uspto-grants-2010_10

反应 SMILES

[C:1]([CH2:4][CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:14]=[C:15]([C:20]3[CH:25]=[CH:24][C:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:22][CH:21]=3)[CH:16]=[CH:17][C:18]=2[OH:19])=[CH:9][C:8]=1[C:31]([CH3:34])([CH3:33])[CH3:32])(=[O:3])[CH3:2].C(=O)([O-])[O-].[Cs+].[Cs+].Br[CH2:42][CH2:43][CH2:44][CH2:45][O:46][Si:47]([C:50]([CH3:53])([CH3:52])[CH3:51])([CH3:49])[CH3:48]>CN(C)C=O>[C:1]([CH2:4][CH2:5][NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:14]=[C:15]([C:20]3[CH:21]=[CH:22][C:23]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:24][CH:25]=3)[CH:16]=[CH:17][C:18]=2[O:19][CH2:42][CH2:43][CH2:44][CH2:45][O:46][Si:47]([C:50]([CH3:51])([CH3:53])[CH3:52])([CH3:48])[CH3:49])=[CH:9][C:8]=1[C:31]([CH3:33])([CH3:32])[CH3:34])(=[O:3])[CH3:2]