Sodium Hydroxide → HCID 11618907, compound

HRID 1158167Notes

Reaction equation

[CH2:1]([N:3]([CH2:33][CH3:34])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[C:12]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([O:29]CC)=[O:28])=[CH:23][CH:22]=3)[CH:13]=[CH:14][C:15]=2[O:16][CH2:17][CH2:18][CH2:19][OH:20])=[CH:6][C:5]=1[CH3:32])[CH3:2].[OH-].[Na+]>>[CH2:33]([N:3]([CH2:1][CH3:2])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[C:12]([C:21]3[CH:22]=[CH:23][C:24]([C:27]([OH:29])=[O:28])=[CH:25][CH:26]=3)[CH:13]=[CH:14][C:15]=2[O:16][CH2:17][CH2:18][CH2:19][OH:20])=[CH:6][C:5]=1[CH3:32])[CH3:34]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 11547132HCID 11547132, compound

Product 1

HCID 11618907HCID 11618907, compoundYield 46.1%

Procedure

In a manner similar to that of Example 12a, by reacting 130 mg (0.3 mmol) of ethyl 4″-diethylamino-4′-(3-hydroxypropoxy)-3″-methyl[1,1′;3′,1″]terphenyl-4-carboxylate (Example 15d) with 3 mL of 1N sodium hydroxide solution. 60 mg of 4″-diethylamino-4′-(3-hydroxypropoxy)-3″-methyl[1,1′;3′,1″]terphenyl-4-carboxylic acid are obtained in the form of a white solid (yield=46%, m.p.=208° C.).

Sources & evidence

ORD record: ord-3774b15f9084417682e74f5b0973f010
Source dataset: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07807708B2

Reaction notes

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