Potassium Carbonate → Ethyl 3''-tert-butyl-4-hydroxy-4''-pyrrolidin-1-yl[1,1';3',1'']terphenyl-4-carboxylate

Participants

Reaction Steps

In a manner similar to that of Example 1d, by reacting 1 g of ethyl 3′-bromo-4′-hydroxy-biphenyl-4-carboxylate (3 mmol) with 1.2 g of 3-tert-butyl-4-pyrrolidinophenylboronic acid (4.5 mmol) in the presence of 5 mL of 2M potassium carbonate (10 mmol) and 360 mg of tetrakis(triphenylphosphine)palladium (Pd(PPh3)4), 900 mg of ethyl 3″-tert-butyl-4′-hydroxy-4″-pyrrolidin-1-yl[1,1′;3′,1″]terphenyl-4-carboxylate are obtained (yield=63%) in the form of a yellow solid.

Provenance & Evidence