HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dibromobutane → 1-(4-Bromo-2-(trifluoromethyl)phenyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dibromobutane | HCID 8056 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromo-2-(trifluoromethyl)aniline | HCID 67960 | — |
| Product | 1-(4-Bromo-2-(trifluoromethyl)phenyl)pyrrolidine | HCID 66672175 | 17.3% |
Reaction Steps
In a manner similar to that of Example 18a, by reacting 40 g of 4-bromo-2-trifluoromethylphenylamine (0.167 mol) with 16.6 g of sodium hydride (0.42 mol) and 49.7 mL of 1,4-dibromobutane (0.42 mol), 8.5 g of 1-(4-bromo-2-trifluoromethylphenyl)pyrrolidine (yield=17%) are obtained in the form of a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807708B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-2a922975bc594f878892f97c077222dc |
| Source note | uspto-grants-2010_10 |