Sodium Hydroxide → HCID 11561969, compound

HRID 1158176Notes

Reaction equation

HRID 1158176 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([C:16]2[CH:17]=[C:18]([C:27]3[CH:32]=[CH:31][C:30]([C:33]([O:35]CC)=[O:34])=[CH:29][CH:28]=3)[CH:19]=[CH:20][C:21]=2[CH2:22][CH:23]([OH:26])[CH2:24][OH:25])[CH:8]=[CH:9][C:10]=1[N:11]([CH2:14][CH3:15])[CH2:12][CH3:13])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].C(C1C=C(C2C=C(C3C=CC(C(O)=O)=CC=3)C=CC=2CCCO)C=CC=1N(CC)CC)(C)(C)C>>[C:1]([C:5]1[CH:6]=[C:7]([C:16]2[CH:17]=[C:18]([C:27]3[CH:28]=[CH:29][C:30]([C:33]([OH:35])=[O:34])=[CH:31][CH:32]=3)[CH:19]=[CH:20][C:21]=2[CH2:22][CH:23]([OH:26])[CH2:24][OH:25])[CH:8]=[CH:9][C:10]=1[N:11]([CH2:12][CH3:13])[CH2:14][CH3:15])([CH3:3])([CH3:4])[CH3:2]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 11525429[1,1′:3′,1′′-Terphenyl]-4-carboxylic acid, 4′′-(diethylamino)-3′′-(1,1-dimethylethyl)-4′-(3-hydroxypropyl)-HCID 11641897HCID 11641897, compound

Product 1

HCID 11561969HCID 11561969, compoundYield 86%

Procedure

In a manner similar to that of Example 3, by reacting 70 mg of ethyl 3″-tert-butyl-4″-diethylamino-4′-(2,3-dihydroxypropyl)-[1,1′;3′,1″]terphenyl-4-carboxylate (0.14 mmol) with 0.2 mL of 1N sodium hydroxide solution, 58 mg of 3″-tert-butyl-4″-diethylamino-4′-(3-hydroxypropyl)-[1,1′;3′,1″]terphenyl-4-carboxylic acid are obtained (yield=86%) in the form of a white solid (m.p.=130° C.).

Sources & evidence

ORD record
ord-1be0bf270822462da14f19a6a5cf3817
Source dataset
uspto-grants-2010_10
Patent number
US07807708B2

Reaction notes

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