HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 2-tert-Butylamino-4-[4-fluoro-phenylethynyl]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | 2-Chloro-4-[2-(4-fluorophenyl)ethynyl]pyrimidine | HCID 12165231 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-tert-Butylamino-4-[4-fluoro-phenylethynyl]pyrimidine | HCID 11608712 | — |
Reaction Steps
A solution of 2-chloro-4-(4-fluoro-phenylethynyl)-pyrimidine (1 equiv.) in tert-butylamine (0.2 M) is heated at 80° C. in a sealed tube for 24 h. The mixture is cooled to rt, diluted with water, and extracted with EtOAc. The organic layer is concentrated and the residue purified by column chromatography to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807832B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-c4289830bc1d47bebc8e3d17f796d90d |
| Source note | uspto-grants-2010_10 |