Nitric Acid → HCID 178526897, compound

HRID 1158283Notes

Reaction equation

HRID 1158283 reaction equation
[Cl:1][C:2]1[NH:3][C:4]([I:8])=[C:5](I)[N:6]=1.S(=O)(=O)(O)O.O.N.[N+:16]([O-])([OH:18])=[O:17]>>[Cl:1][C:2]1[NH:3][C:4]([I:8])=[C:5]([N+:16]([O-:18])=[O:17])[N:6]=1

Participants

5

Reactant 4

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 12896473Azane;hydrateHCID 230802602-Chloro-4,5-diiodoimidazole

Product 1

HCID 178526897HCID 178526897, compoundYield 81.2%

Procedure

2-Chloro-4,5-diiodoimidazole (354 mg) was suspended in concentrated nitric acid (d. 1.42) (5 ml), under ice-cooling, concentrated sulfuric acid (1 ml) was added, and was stirred at a room temperature for 15 hours. Reaction mixture was poured in ice-water, and ammonia water was added to adjust pH 3, the deposited matters were collected by filtration and dried, there was obtained 2-chloro-5-iodo-4-nitroimidazole (222 mg, yield: 81.2%) as yellow solid product.

Workup

  1. temperaturecooling
  2. customReaction mixture
  3. filtrationthe deposited matters were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-093e89095bba4bfe8728805739447df6
Source dataset
uspto-grants-2010_10
Patent number
US07807843B2

Reaction notes

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