反应详情

温度

72.5 °C

4-[4-(4-Trifluoromethoxyphenoxy)piperidin-1-yl]phenol (693 mg) was dissolved in N,N-dimethylformamide (3 ml), then under ice-cooling condition, sodium hydride (86 mg) was added, the reaction mixture was stirred at 70-75° C. for 20 minutes. The reaction mixture was ice-cooled, a solution prepared by dissolving (R)-2-bromo-4-nitro-1-(2-methyl-2-oxiranylmethyl)imidazole (720 mg) prepared in example 6 in N,N-dimethylformamide (3 ml) was added and stirred at 70-75° C. for 20 minutes. The reaction mixture was turned back to a room temperature, ice-water (25 ml) was added, and extracted 3 times with dichloromethane (50 ml). The organic layers were combined, after being washed with water 3 times, the organic layer was dried over anhydrous magnesium sulfate. After being filterated under a reduced pressure, the filtrate was concentrated, and the obtained residue was purified by use of a silica gel column chromatography (eluent: dichloromethane/ethyl acetate=3/1). Recrystallized from ethyl acetate/diisopropyl ether, there was obtained (R)-2-methyl-6-nitro-2-{4-[4-(4-trifluoromethoxyphenoxy)piperidin-1-yl]phenoxymethyl}-2,3-dihydroimidazo[2,1-b]oxazole (343 mg, yield: 33%) as pale yellow powder product.

1. additionwas added
2. temperaturecooled
3. customa solution prepared
4. additionwas added
5. stirringstirred at 70-75° C. for 20 minutes
6. customwas turned back to a room temperature
7. extractionextracted 3 times with dichloromethane (50 ml)
8. washafter being washed with water 3 times
9. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
10. concentrationthe filtrate was concentrated
11. customthe obtained residue was purified by use of a silica gel column chromatography (eluent: dichloromethane/ethyl acetate=3/1)
12. customRecrystallized from ethyl acetate/diisopropyl ether