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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1158313Generated: October 30, 2026

1-(t-Butyldimethylsilanyloxy)-3-chloro-2-(tetrahydropyran-2-yloxy)propane → 1-[3-(Tert-butyldimethylsilanyloxy)-2-(tetrahydropyran-2-yloxy)propyl]-2-chloro-4-nitroimidazole

https://huagongshe.com/reaction/1158313

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(t-Butyldimethylsilanyloxy)-3-chloro-2-(tetrahydropyran-2-yloxy)propaneHCID 23080237—
ReactantHCID 178526855HCID 178526855—
Product1-[3-(Tert-butyldimethylsilanyloxy)-2-(tetrahydropyran-2-yloxy)propyl]-2-chloro-4-nitroimidazoleHCID 6658930674.3%

Reaction Steps

Similar to Example 28, the objective compound was synthesized from 2-chloro-4-nitroimidazole (2.15 g) and 1-(tert-butyldimethylsilanyloxy)-3-chloro-2-(tetrahydropyran-2-yloxy)propane (12 g), there was obtained 1-[3-(tert-butyldimethylsilanyloxy)-2-(tetrahydropyran-2-yloxy)propyl]-2-chloro-4-nitroimidazole (3.03 g, yield: 74.3%) as colorless liquid product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07807843B2
Source datasetuspto-grants-2010_10
ORD IDord-837835e42af1455db6c0eef1a8cb956a
Source noteuspto-grants-2010_10