HRID1158371

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID68617790

未命名化合物

PRODUCTS

产物

HCID59512561

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID313

Hydrochloric Acid

ClH

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

The title compound is prepared according to Scheme 6 as follows: The solution of (3R,4R)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-[(2-methyl-2-phenyl-propionylamino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (227 mg, 0.319 mmol) in 4N HCl in dioxane (2 mL) is stirred for 6 hrs at room temperature. The volatiles are removed by freeze-drying to give the title compound as white solid. MS [M+H]+=540.2. tR (HPLC, Nucleosil C18HD column, 20-100% CH3CN/H2O/6 min, 100% CH3CN/2 min, CH3CN and H2O containing 0.1% TFA, flow: 1 mL/min): 3.91 min.

WORKUP

后处理

customThe title compound is prepared
customThe volatiles are removed
customby freeze-drying

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-6eb4848f6da5457f90f66093b825442b
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07807709B2
来源说明: uspto-grants-2010_10

反应SMILES

C(OC([N:8]1[CH2:12][C@@H:11]([CH2:13][NH:14][C:15](=[O:25])[C:16]([CH3:24])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[C@H:10]([CH2:26][N:27]([CH:44]([CH3:46])[CH3:45])[C:28](=[O:43])[C:29]2[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH2:38][CH2:39][CH2:40][O:41][CH3:42])[CH:30]=2)[CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[CH:44]([N:27]([CH2:26][C@H:10]1[C@H:11]([CH2:13][NH:14][C:15](=[O:25])[C:16]([CH3:24])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH2:12][NH:8][CH2:9]1)[C:28](=[O:43])[C:29]1[CH:34]=[CH:33][C:32]([O:35][CH3:36])=[C:31]([O:37][CH2:38][CH2:39][CH2:40][O:41][CH3:42])[CH:30]=1)([CH3:46])[CH3:45]