Cyclopropylamine → HCID 68616132, compound

Participants

Reaction Steps

From (3R,4S)-3-({[4-methyl-3-(3-methoxy-propoxy)-benzoyl]-isopropyl-amino}-methyl)-4-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester (3 g, 6.29 mmol), cyclopropyl amine (0.395 mL, 6.92 mmol) and NaBHOAc3 (1.87 g, 8.81 mmol) and purification by flash chromatography on silica gel (AcOEt/MeOH 100:0 to 85:15) to give the title compound as colorless oil. TLC, Rf (AcOEt)=0.63. MS (LC-MS): 518.3 [M+H]+; tR (HPLC, Nucleosil C-18HD (4×70 mm, 3 μm), 20-100% CH3CN/H2O/6 min, 100% CH3CN/1.5 min; flow: 1 mL/min): 5.37 min.

Provenance & Evidence