Chloride → HCID 68616792, compound

Participants

Reaction Steps

From (3R,4R)-3-({[4-methyl-3-(3-methoxy-propoxy)-benzoyl]-isopropyl-amino}-methyl)-4-cyclopropylaminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester (0.3 g, 0.579 mmol), phenylacethyl chloride (0.092 mL, 0.695 mmol) and triethylamine (0.12 mL, 0.869 mmol) and purification by flash chromatography (c-hexane/AcOEt 1:1 to 0:1) to give the title compound as colorless oil. TLC, Rf (AcOEt/c-hexane 4:1)=0.15. MS (LC-MS): 610.3 [M+H]+; (LC-MS Waters Symmetry C18, 2.1×30 mm, 20-100% CH3CN/5 min): 4.63 min.

Provenance & Evidence