Triethylamine → tert-butyl (3S,4R)-3-(2-tert-butylsilyloxypropan-2-yl)-4-[[[1-(3-methoxypropyl)indole-6-carbonyl]-propan-2-ylamino]methyl]pyrrolidine-1-carboxylate

Participants

Reaction Steps

From (3S,4R)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-(isopropylamino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester (5 g, 12.9 mmol), 1-(3-methoxy-propyl)-1H-indole-6-carboxylic acid (4.22 g, 18.1 mmol), BOPCI (4.6 g, 18.1 mmol) and triethylamine (7.2 mL, 51.7 mmol). TLC, Rf (AcOEt)=0.32.

Provenance & Evidence