Acetonitrile → HCID 86622398, compound

HRID 1158438Notes

Reaction equation

HRID 1158438 reaction equation
C(N(C)[C:9]([Cl:11])=[O:10])C1C=CC=CC=1.[CH:13]1([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:15][CH2:14]1.CC#N.O.CC#N>O>[C:17]1([N:16]([CH:13]2[CH2:15][CH2:14]2)[C:9]([Cl:11])=[O:10])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

6

Reactant 4

HCID 6342AcetonitrileHCID 7016287N-CyclopropylanilineHCID 10464985N-benzyl-N-methylcarbamoyl chlorideHCID 18373917Acetonitrile--water (1/1)2×

Product 1

HCID 86622398HCID 86622398, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared analogously as described for benzyl-methyl-carbamoyl chloride from cyclopropyl-phenyl-amine prepared according to 0 Synlett 2003, 14, 2139. MS (LC-MS): [M+H]+=196.2. tR (HPLC, Waters Symmetry C18 column, 20-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.6 mL/min): 4.44 min.

Workup

  1. customprepared
  2. custom4.44 min.

Sources & evidence

ORD record
ord-7d732f21f81c47b18d4e7f8f79e41c59
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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