HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boron tribromide → 4-Ethyl-3-hydroxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boron tribromide | HCID 25134 | — |
| Reactant | 4-Ethyl-3-(3-methoxypropoxy)benzoic acid | HCID 57355538 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Ethyl-3-hydroxybenzoic acid | HCID 21506442 | — |
Reaction Steps
To a solution of 4-ethyl-3-(3-methoxy-propoxy)-benzoic acid (6.44 g, 27.03 mmol) in CH2Cl2 (150 mL) at −78° C. is slowly added BBr3 (9 mL, 93.41 mmol). The reaction mixture is allowed to reach RT and stirred for 3 hours, then poured into ice/water and filtrated to afford the title product as a white solid. TLC, Rf (CH2Cl2/MeOH 95:5)=0.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807709B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-d76ef5728a66498ba1ebf12bd22f6729 |
| Source note | uspto-grants-2010_10 |