Potassium Carbonate → 4-Methoxy-3-(4,4,4-trifluoro-butoxy)-benzoic acid ethyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Bromo-1,1,1-trifluorobutane	HCID 521006	—
반응물	Ethyl 3-hydroxy-4-methoxybenzoate	HCID 15480330	—
용매	Acetonitrile	HCID 6342	—
생성물	4-Methoxy-3-(4,4,4-trifluoro-butoxy)-benzoic acid ethyl ester	HCID 68617480	—

반응 단계

A suspension of 3-hydroxy-4-methoxy-benzoic acid ethyl ester (1.00 g, 5.10 mmol), 1-bromo-4,4,4-trifluorobutane (1.12 g, 5.86 mmol) and anhydrous K2CO3 (2.14 g, 15.3 mmol) in MeCN (10 mL) is refluxed with stirring overnight. After cooling, the mixture is filtered, and the filtrates are evaporated to drying to give the title compound as white solid. TLC, Rf (hexane/AcOEt 1:1)=0.62. MS: 307.0 [M+H]+. 1H-NMR (CDCl3): δ 1.42 (m, 3H), 2.1-2. (m, 2H), 2.3-2.45 (m, 2H), 3.95 (s, 3H), 4.14 (m, 2H), 4.39 (m, 2H), 6.93 (dd, 1H), 7.58 (d, 1H), 7.74 (dd, 1H) ppm.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07807709B2
출처 데이터셋	uspto-grants-2010_10
ORD ID	ord-797d690fb48147d99579496445433fe9
출처 메모	uspto-grants-2010_10