1,4-Dioxane hydrochloride → HCID 59512260, compound

HRID 1158492Notes

Reaction equation

HRID 1158492 reaction equation
Cl.O1CCOCC1.C(OC([N:15]1[CH2:19][C@H:18]([CH2:20][N:21]([CH2:31][CH:32]([CH3:34])[CH3:33])[S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])[C@H:17]([CH2:35][N:36]([CH:53]([CH3:55])[CH3:54])[C:37](=[O:52])[C:38]2[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[C:40]([O:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51])[CH:39]=2)[CH2:16]1)=O)(C)(C)C>O1CCOCC1>[CH:53]([N:36]([CH2:35][C@H:17]1[C@H:18]([CH2:20][N:21]([CH2:31][CH:32]([CH3:34])[CH3:33])[S:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)(=[O:24])=[O:23])[CH2:19][NH:15][CH2:16]1)[C:37](=[O:52])[C:38]1[CH:43]=[CH:42][C:41]([O:44][CH3:45])=[C:40]([O:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51])[CH:39]=1)([CH3:55])[CH3:54]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68618081HCID 68618081, compound

Product 1

HCID 59512260HCID 59512260, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4N HCl/dioxane (4 mL) is added to a solution of (3R*,4R*)-3-({isopropyl-[4-methoxy-3-(3-methoxy-propoxy)-benzoyl]-amino}-methyl)-4-[(isobutyl-phenylsulfonyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (0.804 g, 1.17 mmol) in dioxane (5 mL). After 3 h the solution is lyophilized to give the title compound a colorless powder. MS (LC-MS): 590.3 [M+H]+; tR (HPLC, Macherey-Nagel Nucleosil C18 column, 10-100% CH3CN/H2O/5 min, 100% CH3CN/3 min, CH3CN and H2O containing 0.1% TFA, flow: 1.5 mL/min): 4.91 min.

Sources & evidence

ORD record
ord-54b6a2a2dcd04c7fb93492f6dcab6021
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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