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HRID1158493

反应详情

EQUATION

反应方程式

HRID 1158493 的结构方程式

REACTANTS

反应物

4
结构：CC#N
HCID6342

Acetonitrile

C2H3N

结构：CC(C)CN
HCID6558

Isobutylamine

C4H11N

结构：CC#N.O
HCID18373917

Acetonitrile--water (1/1)

C2H5NO

2 次

结构：CC(C)(C)OC(=O)N1C[C@@H](C=O)[C@H](C(C)(C)O[SiH2]C(C)(C)C)C1
HCID131728359

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)CNC[C@@H]1CN(C(=O)OC(C)(C)C)C[C@H]1C(C)(C)O[SiH2]C(C)(C)C
HCID131728367

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

The title compound is prepared as described above for Example 9/step F (Scheme 5) from (3S*,4S*)-3-(tert-butyl-dimethyl-silanyloxymethyl)-4-formyl-pyrrolidine-1-carboxylic acid tert-butyl ester and isobutylamine. MS (LC-MS): 401.1 [M+H]+; tR (HPLC, Waters Symmetry C18 column, 20-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow: 0.6 mL/min): 3.70 min.

WORKUP

后处理

  1. custom3.70 min.