Acetonitrile → HCID 86622402, compound

HRID 1158495Notes

Reaction equation

HRID 1158495 reaction equation
[OH:1][CH2:2][C@@H:3]1[CH2:7][NH:6][CH2:5][C@H:4]1[CH2:8][N:9]([CH2:19][CH:20]([CH3:22])[CH3:21])[S:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:12])=[O:11].CC#N.O.CC#N>O>[CH:2]([C@@H:3]1[CH2:7][NH:6][CH2:5][C@H:4]1[CH2:8][N:9]([CH2:19][CH:20]([CH3:22])[CH3:21])[S:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:12])=[O:11])=[O:1]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 18373917Acetonitrile--water (1/1)2×HCID 68618246HCID 68618246, compound

Product 1

HCID 86622402HCID 86622402, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound is prepared as described above for Example 9/step E (Scheme 5) from N-((3S*,4S*)-4-Hydroxymethyl-pyrrolidin-3-ylmethyl)-N-isobutyl-benzenesulfonamide. MS (LC-MS): 325.0 [M-Boc+H]+; tR (HPLC, Waters Symmetry C18 column, 20-95% CH3CN/H2O/3.5 min, 95% CH3CN/H2O, 2 min, CH3CN and H2O containing 0.1% TFA, flow 0.6 mL/min): 4.24 min.

Workup

  1. custom4.24 min.

Sources & evidence

ORD record
ord-51a6acb239ed49729d80d6c693baccc5
Source dataset
uspto-grants-2010_10
Patent number
US07807709B2

Reaction notes

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