HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → HCID 11602839, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (Phenylmethyl)hydrazine | HCID 11157 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | N-Carbobenzoxy-L-valine | HCID 726987 | — |
| Product | HCID 11602839 | HCID 11602839 | 66% |
Reaction Steps
The general procedure for the preparation of hydrazides described above was followed using Cbz-(L)-valine (0.540 g, 2.15 mmol), EDAC (0.450 g, 2.35 mmol), HOBT (0.320 g, 2.37 mmol), NMM (0.260 mL, 2.36 mmol), benzylhydrazine×2HCl (0.500 g, 2.56 mmol) and Et3N (0.710 mL, 5.09 mmol) which gave the title compound (0.502 g, 66%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807677B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-07aa4bb555a04839afecdd7c4f7dcfd7 |
| Source note | uspto-grants-2010_10 |