HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → [(1S)-1-(N'-Benzyl-hydrazinocarbonyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (Phenylmethyl)hydrazine | HCID 11157 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | (2S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoic acid | HCID 9899995 | — |
| Product | [(1S)-1-(N'-Benzyl-hydrazinocarbonyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester | HCID 11639262 | 67% |
Reaction Steps
The general procedure for the preparation of hydrazides described above was followed using Cbz-(L)-tert-leucine (2.00 g, 4.48 mmol), EDAC (0.969 g, 5.05 mmol), HOBT (0.669 g, 4.95 mmol), NMM (0.542 mL, 4.93 mmol), benzylhydrazine×2HCl (0.962 g, 4.93 mmol) and Et3N (1.38 mL, 9.85 mmol) which gave the title compound (1.11 g, 67%) as a low melting solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807677B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-f85c6b1f04f343e9bd427e0c46571b98 |
| Source note | uspto-grants-2010_10 |