Benzyloxyamine hydrochloride → HCID 72311086, compound

Participants

Reaction Steps

To a solution of 5-hydroxy-5,6-dihydro-cyclopenta[b]thiophen-4-one (33.4 g, 0.216 mol) in pyridine (300 mL) was added O-benzylhydroxylamine hydrochloride (38.3 g, 0.240 mol) and the mixture was stirred at room temperature over weekend. The mixture was evaporated under reduced pressure and co-evaporated two times with toluene. Ethyl acetate was added and the organic phase was washed with 5% citric acid and brine. The organic phase was dried with sodium sulphate and evaporated under reduced pressure. Yield. 55.1 g=98%

Provenance & Evidence