HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 11549423, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (2H-1,3-benzodioxol-5-yl)boronic acid | HCID 2734371 | — |
| Reactant | HCID 11513133 | HCID 11513133 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 11549423 | HCID 11549423 | — |
Reaction Steps
The title compound was prepared according to Method B, using compound 19 (91.9 mg, 0.135 mmol), 3,4-methylenedioxyphenylboronic acid (112 mg, 0.676 mmol), Pd(PPh)3Cl2 (4.70 mg, 0.0067 mmol), 2 M Na2CO3 (aq., 0.203 mL, 0.405 mmol), EtOH (0.4 mL) and DME (1.6 mL). Purification by RP-LC-MS (35 min gradient of 30-100% CH3CN in 0.05% aqueous formic acid) afforded the product (47.7 mg, 49%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807677B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-cfcc9b8e93f6435eb1accd796677d5eb |
| Source note | uspto-grants-2010_10 |