HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dimethoxyethane → HCID 11571120, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dimethoxyethane | HCID 8071 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | HCID 11693236 | HCID 11693236 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 11571120 | HCID 11571120 | — |
Reaction Steps
The title compound was prepared according to Method B using compound 26 (80.5 mg, 0.118 mmol), phenylboronic acid (72.5 mg, 0.595 mmol), Pd(PPh3)2Cl2 (6.50 mg, 0.00926 mmol), 2 M Na2CO3 (aq., 0.177 mL, 0.354 mmol), DME (1.6 mL) and EtOH (0.4 mL) affording the product (21.2 mg, 26%) after RP-LC-MS (35 min gradient of 40-100% CH3CN in 0.05% aqueous formic acid) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807677B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-71189a536ac74e03ba4662f013a3164c |
| Source note | uspto-grants-2010_10 |