HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 11527707, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Ethynylpyridine | HCID 137268 | — |
| Reactant | HCID 11693236 | HCID 11693236 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 11527707 | HCID 11527707 | — |
Reaction Steps
The title compound was synthesized according to Method C using compound 26 (79.4 mg, 0.117 mmol), 2-(ethynyl)pyridine (15.3 mg, 0.148 mmol), Et2NH (0.105 mL, 1.01 mmol) Pd(PPh3)2Cl2 (6.50 mg, 0.00926 mmol), CuI (1.50 mg, 0.00788 mmol) and DMF (2 mL). RP-LC-MS (35 min gradient of 0-100% CH3CN in 0.05% aqueous formic acid) gave the product (15.9 mg, 19%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807677B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-97d29b87cc08467195d84c0dc8e4cd22 |
| Source note | uspto-grants-2010_10 |