Tetrabutylammonium Fluoride → HCID 44819176, compound

Participants

Reaction Steps

TBAF (0.274 g, 1.05 mmol, 1M in THF) was added to a solution of (R)-2-benzyl-4-(tert-butyl-diphenyl-silanyloxy)-1-((3aS,8aR)-2,2-dimethyl-8,8a-dihydro-3 aH-indeno[1,2-d]oxazol-3-yl)-2-hydroxy-butan-1-one (46) (0.325 g, 0.52 mmol) in THF (20 mL) at room temperature and stirred for 3 h. The solvent was evaporated and the residue dissolved in dichloromethane and washed with water and brine, dried and evaporated. The product was purified by flash chromatography using petroleum ether:acetone (4:1) which gave 0.140 g of the title compound in 53% yield from two steps.

Provenance & Evidence