2,2-Dimethoxypropane → HCID 10632081, compound

Participants

Reaction Steps

A solution of (S)-2-Hydroxy-3-phenyl-propionic acid (1.662 g, 10.0 mmol), 2,2-dimethoxypropane (8.328 g, 80.0 mmol) and PPTSA (1.257 g, 5.0 mmol) in chloroform was stirred at 70° C. for one hour, concentrated, dissolved in dichloromethane and purified on silica gel with 10% EtOAc-PE which gave the title compound (2.010 g, 97%) as a white solid.

Provenance & Evidence