Methyl Acrylate → HCID 24799843, compound

Participants

Reaction Steps

To a solution of compound 56 (3.180 g, 15.42 mmol) in THF was added 9.42 mL LDA (1.8 M in THF, 16.96 mmol) at −78° C. Methyl acrylate (1.460 g, 16.96 mmol) was added to the solution at −78° C. after 15 min. After 1 h the reaction was quenched with saturated NH4Cl aqueous solution, extracted with EtOAc 3×30 mL, dried with MgSO4 and purified on silica gel with 8-17% EtOAc-PE which gave the title compound (2.418 g, 54%) as colorless oil.

Provenance & Evidence