3-Methoxyphenylacetic acid hydrazide → HCID 178490028, compound

HRID 1158628Notes

Reaction equation

HRID 1158628 reaction equation
[OH:1][C:2]1[C:3]([C:12]#[N:13])=[N:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH2:22][C:23]([NH:25][NH2:26])=O)[CH:19]=[CH:20][CH:21]=1>>[CH3:14][O:15][C:16]1[CH:17]=[C:18]([CH:19]=[CH:20][CH:21]=1)[CH2:22][C:23]1[NH:13][C:12]([C:3]2[C:2]([OH:1])=[C:11]3[C:6]([CH:7]=[CH:8][CH:9]=[N:10]3)=[CH:5][N:4]=2)=[N:26][N:25]=1

Participants

3

Reactant 2

HCID 27749783-Methoxyphenylacetic acid hydrazideHCID 595135008-Hydroxy-1,6-naphthyridine-7-carbonitrile

Product 1

HCID 178490028HCID 178490028, compound

Procedure

The title compound was prepared in a similar manner to that described in example 1 from of 8-hydroxy-1,6-naphthyridine-7-carbonitrile (50 mg, 0.29 mmol) and 2-(3-methoxyphenyl)acetic hydrazide (270 mg, 1.5 mmol) as a yellow solid (20 mg, 21%). 1H NMR (CDCl3): δ 9.19 (m, 1 H), 8.91 (s, 1 H), 8.31 (d, J=7.6 Hz, 1 H), 7.63 (m, 1 H), 7.22 (m, 1 H), 7.01-6.97 (m, 2 H), 6.83-6.79 (m, 2 H), 4.23 (s, 2 H), 3.79 (s, 3 H); MS m/z 334 (M+1).

Sources & evidence

ORD record
ord-e17b6b3292114ca0a009aa8c21c3e2df
Source dataset
uspto-grants-2010_10
Patent number
US07812016B2

Reaction notes

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