反应详情

A solution of 2-bromo-4-phenylpyridine (1.34 g, 5.72 mmol), 1-(tert-butoxycarbonyl)piperazine (3.19 g, 17.2 mmol) and pyridine (20 ml) was stirred at 125° C. for 7 days, and the solvent was distilled away under reduce pressure. To the residue was added water, and extracted with ethyl acetate. The extract was washed with water, and the solvent was distilled away under reduce pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to give the titled compound 390 mg (20.1%) as solid product.

1. distillationthe solvent was distilled away
2. additionTo the residue was added water
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water
5. distillationthe solvent was distilled away
6. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1)