HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-2-methyl-1-propene → 2-amino-9-(2-methylprop-2-en-1-yl)-9H-pyrido[2,3-b]indole-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-2-methyl-1-propene | HCID 357785 | — |
| Reactant | 2-amino-9H-pyrido[2,3-b]indole-3-carboxamide | HCID 15270984 | — |
| Reactant | 2-amino-9-isopropyl-9H-pyrido[2,3-b]indole-3-carboxamide | HCID 24900676 | — |
| Product | 2-amino-9-(2-methylprop-2-en-1-yl)-9H-pyrido[2,3-b]indole-3-carboxamide | HCID 59513643 | 59% |
Reaction Steps
2-Amino-9H-pyrido[2,3-b]indole-3-carboxamide (5, 196 mg, 0.866 mmol) was alkylated with methallyl bromide (0.131 mL, 1.30 mmol) according to the procedure detailed in the synthesis of 13 to afford 2-amino-9-(2-methylprop-2-en-1-yl)-9H-pyrido[2,3-b]indole-3-carboxamide (xii-a, 143 mg, 59%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812018B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-2375f48e8e35404ba6b9bc11a8a68980 |
| Source note | uspto-grants-2010_10 |