HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol → (r)-Tert-butyl 1-(2-amino-3-carbamoyl-9h-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-(+)-3-Benzyloxy-2-(Boc-amino)-1-propanol | HCID 11065873 | — |
| Reactant | (S)-(2-Iodo-1-methyl-ethyl)-carbamic acid tert-butyl ester | HCID 15529790 | — |
| Reactant | tert-butyl (1-{[2-amino-3-(aminocarbonyl)-9H-pyrido[2,3-b]indol-9-yl]methyl}cyclopropyl)carbamate | HCID 24901061 | — |
| Reactant | HCID 66675623 | HCID 66675623 | — |
| Reactant | N-Boc-1-(iodomethyl)cyclopropanamine | HCID 86648312 | — |
| Product | (r)-Tert-butyl 1-(2-amino-3-carbamoyl-9h-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate | HCID 59613115 | — |
Reaction Steps
(R)-tert-butyl 1-(2-amino-3-carbamoyl-9H-pyrido[2,3-b]indol-9-yl)-3-(benzyloxy)propan-2-ylcarbamate (xvi-d) was prepared following the procedure detailed in the preparation of 63, substituting (S)-tert-butyl 1-(benzyloxy)-3-iodopropan-2-ylcarbamate (prepared as detailed in the synthesis of xxvii from commercial N-Boc-L-Ser(Bzl)-ol) for tert-butyl[1-(iodomethyl)cyclopropyl]carbamate. NH4OAc QC conditions. M+H=490.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812018B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-8910a69928bb45f2bc92dde816aee193 |
| Source note | uspto-grants-2010_10 |