HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-ethyl-2-(methylamino)-9H-pyrido[2,3-b]indole-3-carboxamide → tert-butyl{(1S)-2-[3-(aminocarbonyl)-2-(methylamino)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-ethyl-2-(methylamino)-9H-pyrido[2,3-b]indole-3-carboxamide | HCID 24900932 | — |
| Reactant | tert-butyl {(1S)-2-[2-amino-3-(aminocarbonyl)-9h-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate | HCID 59513639 | — |
| Product | tert-butyl{(1S)-2-[3-(aminocarbonyl)-2-(methylamino)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate | HCID 59513645 | 89% |
Reaction Steps
tert-butyl{(1S)-2-[2-amino-3-(aminocarbonyl)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate (xvi-b, 20 mg, 0.052 mmol) was alkylated according to procedure detailed in the preparation of 48, to afford tert-butyl{(1S)-2-[3-(aminocarbonyl)-2-(methylamino)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate (xxxii-a, 20 mg, 89%). NH4OAc QC conditions. M+H=398.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812018B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-02f9b21527d4454f9db4f3dcf002d877 |
| Source note | uspto-grants-2010_10 |