HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 5,6,7,8-Tetrahydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | 2-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrazine | HCID 53393357 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5,6,7,8-Tetrahydro-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrazine | HCID 34176329 | — |
Reaction Steps
2-(Trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrazine (340 mg, 1.81 mmol, from Step C) was hydrogenated under atmospheric hydrogen with 10% palladium on carbon (60 mg) as a catalyst in ethanol (10 mL) at ambient temperature for 18 h. Filtration through Celite followed by concentration gave a dark colored oil. Flash chromatography (100% ethyl acetate, then 10% methanol/dichloromethane) gave the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07812027B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-3817a062affb454f9afcb2116a3d6cbc |
| Source note | uspto-grants-2010_10 |