Benzyl Bromide → HCID 86610921, compound

Participants

Reaction Steps

The mixture of 2-dimethylamino-4-(3,4-dichlorophenyl)pyrimidine-5-carboxylic acid [2-hydroxy-2-(3-hydroxyphenyl)ethyl]methylamide (0.92 g, 2 mmol), benzylbromide (1.71 g, 10 mmol), cesium carbonate (1.30 g, 4 mmol) and acetonitrile (25 ml) are boiled under stirring for 5 hours. The reaction mixture is evaporated in vacuum, dichloromethane (50 ml) is added to it, washed with water (3×50 ml), dried over sodium sulphate and evaporated. The residue is chromatographed on silicagel, using dichloromethane—methanol 100/1 mixture as eluent. 0.50 g (45.4%) of pale-yellow crystalline material is obtained, m.p.: 68-70° C.; [M+H]+ 551.

Provenance & Evidence