HCID 10490410, compound → HCID 86610923, compound

Participants

Reaction Steps

To activated 2-dimethylamino-4-phenylpyrimidine-5-carboxylic acid (1.48 g, 1 mmol/g, 1.48 mmol) bound to PS-TFP resin, N,N-dimethylformamide (20 ml), then after 5 minutes of swelling 1-(3-benzyloxyphenyl)-2-(2-hydroxyethylamino)ethanol (0.40 g, 1.39 mmol) is added. The reaction mixture is stirred at room temperature for 18 hours, then filtered and washed consecutively with 50-50 ml of NAN-dimethylformamide, tetrahydrofuran and dichloromethane. After evaporation the resulting oil (0.36 g) is chromatographed on silicagel using chloroform, and chloroform-ethyl acetate 9:1, 4:1 mixtures as eluents. 0.21 g of the title amide is obtained as white solid material, m.p. 89° C.

Provenance & Evidence