(4E)-6-Fluoro-N-methoxy-3,4-dihydro-2H-1-benzopyran-4-imine → 6-fluoro-3,4-dihydro-2H-1-benzopyran-4-amine

HRID 1158798노트

반응식

HRID 1158798 반응식
CO[N:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:14])[CH:12]=2)[O:7][CH2:6][CH2:5]1.CON=C1C2C(=CC=C(C)C=2)OCC1>>[F:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[O:7][CH2:6][CH2:5][CH:4]2[NH2:3]

참가 물질

3

반응물 2

HCID 73696137(4E)-6-Fluoro-N-methoxy-3,4-dihydro-2H-1-benzopyran-4-imineHCID 86605441(4E)-N-Methoxy-6-methyl-3,4-dihydro-2H-1-benzopyran-4-imine

생성물 1

HCID 162444136-fluoro-3,4-dihydro-2H-1-benzopyran-4-amine

실험 절차

The title compound was prepared using the procedure as described in Example 7B, substituting the product of Example 10A for the product of Example 7A. 1H NMR (300 MHz, CDCl3) δ 7.03 (dd, 1H, J=9.1 and 3.1 Hz), 6.85 (m, 1H), 6.74 (m, 1H,), 4.15-4.29 (m, 2H), 4.02 (m, 1H), 2.10-2.20 (m, 1H), 1.79-1.89 (m, 1H). MS (DCI) m/e 168 (M+H)+.

출처 및 근거

ORD 기록
ord-8b58b65805e243af980032e030c89b2b
출처 데이터셋
uspto-grants-2010_10
특허 번호
US07812019B2

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