HCID 67236455, compound → HCID 53251173, compound

HRID 1158799Notes

Reaction equation

HRID 1158799 reaction equation
COC([N:5]1[C:13]2[C:8](=[C:9]([NH:14][C:15]([NH:17][CH:18]3[C:27]4[C:22](=[CH:23][CH:24]=[C:25]([F:28])[CH:26]=4)[O:21][CH2:20][CH2:19]3)=[O:16])[CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6]1)=O.COC(N1C2C(=C(NC(NC3C4C(=CC(C(C)(C)C)=CC=4)OCC3)=O)C=CC=2)C=N1)=O>>[F:28][C:25]1[CH:26]=[C:27]2[C:22](=[CH:23][CH:24]=1)[O:21][CH2:20][CH2:19][CH:18]2[NH:17][C:15]([NH:14][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:8]=1[CH:7]=[N:6][NH:5]2)=[O:16]

Participants

3

Reactant 2

HCID 67236455HCID 67236455, compoundHCID 67236597HCID 67236597, compound

Product 1

HCID 53251173HCID 53251173, compound

Procedure

The title compound was prepared using the procedure as described in Example 1E, substituting the product of Example 10C for the product of Example 1D. 1H NMR (300 MHz, DMSO-d6) δ 13.00 (broad s, 1H), 8.60 (s, 1H), 8.02 (s, 1H), 7.67 (d, J=7.5 Hz, 1H), 7.21 (m, 1H), 7.08-7.00 (m, 3H), 6.92-6.80 (m, 2H), 4.92 (m, 1H), 4.35-4.11 (m, 2H), 2.20-1.93 (m, 2H). MS (DCI) m/e 327 (M+H)+. Calcd. For C17H15N4O2F.0.1H2O: C, 62.23; H, 4.67; N, 17.07. Found: C, 62.31; H, 4.46; N, 16.74.

Sources & evidence

ORD record
ord-63e1fe5adc9a419faffd186935c26076
Source dataset
uspto-grants-2010_10
Patent number
US07812019B2

Reaction notes

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