HCID 66842454, compound → HCID 66842014, compound

HRID 1158833Notes

Reaction equation

HRID 1158833 reaction equation
C(O[C:6](=O)[N:7]([C:9]1[CH:17]=[C:16]2[C:12]([C:13]([S:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]#[N:33])=[CH:14][N:15]2[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:11][CH:10]=1)C)(C)(C)C>C1(C)C=CC=CC=1.CC(C)=O>[CH3:6][NH:7][C:9]1[CH:17]=[C:16]2[C:12]([C:13]([S:25][C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=3[C:32]#[N:33])=[CH:14][N:15]2[CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 1

HCID 66842454HCID 66842454, compound

Product 1

HCID 66842014HCID 66842014, compound

Reagents, catalysts & solvents 1

HCID 20247278Toluene acetoneSolvent

Procedure

v)—Following a procedure analogous to that described under step i of Example 2, the product obtained in the previous step (0.150 g, 0.33 mmol) was methylated to give, after column chromatography (toluene/acetone 8:2), [3-(2-cyano-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester (0.044 g).

Workup

  1. customthe product obtained in the previous step (0.150 g, 0.33 mmol)
  2. customto give

Sources & evidence

ORD record
ord-6898a7aadb194b78a2017f1756275031
Source dataset
uspto-grants-2010_10
Patent number
US07812036B2

Reaction notes

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