Ethyl Acetate → HCID 66842051, compound

Participants

Reaction Steps

[3-(2-Nitro-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indol-6-yl]-carbamic acid tert-butyl ester (Example 2, step iv; 3.4 g, 6.3 mmol) was deprotected to give, after column chromatography (heptane/ethyl acetate 2:8→ethyl acetate, containing some triethylamine), the title compound (1.54 g). 1H-NMR (CDCl3) δ 8.62 (bd, 1H, J=5.0 Hz), 8.26 (dd, 1, J=8.0 and 1.5 Hz), 7.61 (dt, H, J=7.5 and 2.0 Hz), 7.34 (s, 1H), 7.25-7.30 (m, 2H), 7.22 (ddd, 1H, J=7.5, 5.0 and 1.0 Hz), 7.16 (ddd, 1H J=8.0, 7.0 and 1.0 Hz), 7.05 (dd, 1H, J=8.0 and 1.0 Hz), 6.86 (d, 1H, J=8.0 Hz), 6.63 (d, 1H, J=1.5 Hz), 6.60 (dd, 1H, J=8.0 and 1.5 Hz), 5.41 (s, 2H), 3.70 (bs, 2H).

Provenance & Evidence